Manchester United travel to Southampton in Matchweek 4’s opening fixture on Saturday 12:30. Saints recorded their first win of the season at Brighton & Hove Albion last weekend, while Man Utd will be hoping to bounce back from their shock defeat by Crystal Palace.

Chelsea host promoted Sheffield United at Stamford Bridge and Manchester City welcome Brighton to the Etihad Stadium, both on Saturday 15:00. Raheem Sterling will be bidding to extend his goal scoring run for the Premier League champions, having scored in every match this season.

Table-toppers Liverpool take their 100 per cent record to Turf Moor to face Burnley on Saturday 17:30. The Reds will be wary of the threat posed by in-form Burnley striker Ashley Barnes, another player who has netted in all three matches this season.

The weekend’s headline fixture features Arsenal taking on Spurs in the North London derby on Sunday 16:30. In last season’s match at Emirates Stadium, Arsenal came from behind to win 4-2 in a thriller.